transcriptomic alteration – Communicable Diseases Research

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경

Article

Published on 2022-12-012022-09-11
Journal: Protein & Cell
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis.
[DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다

Article

Published on 2022-01-292022-09-11
Journal: Cardiovascular Research
[Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] adverse outcome Analysis Atla Autopsy cardiac Cardiac infection Cardiac signature matrix caused cDNA Cell consequence COVID-19 Cytometry Deceased DEGs destruction Diagnosis differentially expressed gene downregulated Effects endothelial Endothelial cell endothelial cells fraction Gene ontology GO term heart heart tissue ICAM1 identify IFI44L Immune cell Immune cell infiltration immune response Immunofluorescent staining immunohistochemistry In situ hybridization Increased Infection interferon interferon pathway investigated MACE marker massive molecular MYPN no difference NPPB paracrine Pathomechanism positive pro-inflammatory pro-inflammatory gene expression q-value Quantitative reveal RNA-Seq RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2. sequencing data signature matrix single-cell dataset staining tissue transcriptomic alteration TRIM25 upregulated Viral Viral protein virus virus load was performed while
[DOI] 10.1093/cvr/cvab322 PMC 바로가기 [Article Type] Article

Comparative Transcriptomic and Molecular Pathway Analyses of HL-CZ Human Pro-Monocytic Cells Expressing SARS-CoV-2 Spike S1, S2, NP, NSP15 and NSP16 Genes

Article

Published on 2021-05-312022-10-29
Journal: Microorganisms
[Category] COVID-19,

[키워드] antigen processing arising binding bioinformatics cell line Comparative complex complications of COVID-19 contribute COVID-19 pandemic Critical disease down-regulated down-regulated gene down-regulation Endoplasmic reticulum endoribonuclease (NSP15) enrichment analysis expression facilitate global public health heart development Heat shock Host host gene Human Immunity insulin signaling pathway Interaction methyltransferase Methyltransferase (NSP16) nervous system neurodegeneration neutrophil degranulation Nucleocapsid (NP) nucleocapsid protein offer oxidative phosphorylation pathway phosphatidylinositol 3-kinase positive Protein Regulation response RNA sequencing RNA-sequencing S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 proteins SARS-CoV-2 virus Signaling signaling pathway spike Spike S1 Spike S2 Stress target host cell transcriptomic transcriptomic alteration up-regulated viral gene viral spike virus receptor
[DOI] 10.3390/microorganisms9061193 PMC 바로가기 [Article Type] Article

Identification of 37 Heterogeneous Drug Candidates for Treatment of COVID-19 via a Rational Transcriptomics-Based Drug Repurposing Approach

Article

Published on 2021-01-252022-10-28
Journal: Pharmaceuticals
[Category] COVID-19,

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

Article

Published on 2020-06-042022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] “cytokine storm” 229E acute respiratory syndrome alteration Betacoronavirus cause cell signalling pathways Comorbidities Consequences coronavirus Coronavirus-2 COVID-19 COVID-19 disease Critical database decrease effective exacerbated FIVE geographical region greater highest highlight host responses Human identify increased mortality Inflammatory response KEGG KEGG pathway KEGG pathway analysis Lung pathology mechanism MERS microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) miRNA Mutation number of comorbidities OC43 Pandemics pathogenicity pathway Phylogenetic relationship physiological effect prediction reduced reported response responses resulting SARS-CoV-2 SARS-CoV-2 sequence SARS–CoV-2 selected sequence sequence motif Seven Significant significant pathways similarity Symptom the SARS-CoV-2 therapeutic approach transcriptional transcriptomic alteration viral pathogenesis viral pathogenicity virus virus viruses whole-genome
[DOI] 10.3390/v12060614 PMC 바로가기 [Article Type] Article